Javier Nepomuceno, the founder's first son convinced Mr. Ricardo Flores to apply for a government permit to open a College of Commerce. It was he who designed a three-year diploma course following the De La Salle curriculum where he graduated. He also was one of the first group of instructors and became its first Dean. By 1950, he requested his friend and cousin-in-law, Carlos T. Valdes, who was then teaching at De La Salle, to teach auditing every Saturday at Holy Angel. The pioneer graduates numbering 23 received their diplomas in 1951. Thus making the College of Commerce the first full college established at Holy Angel.

In 1965, the graduates of that school year achieved a 100% passing rate in the Certified Public Accountant (CPA) board exam. The next two decades saw the growth of the college. It has grown to be the biggest college of the University because of the growing need of the commercial establishments in Angeles, which became a city in 1964. Despite the natural upheavals, the faculty strike in 1968 espite the natural upheavals, the faculty strike in 1968, the declaration of Martial Law in 1972, and the offering of new courses and colleges, the College of Commerce has continued to grow through the years.

In 1965, the graduates of that school year achieved a 100% passing rate in the Certified Public Accountant (CPA) board exam. The next two decades saw the growth of the college. It has grown to be the biggest college of the University because of the growing need of the commercial establishments in Angeles, which became a city in 1964.